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Yoopan N baclofen 25 mg for sale spasms with ms, Thisoda P generic baclofen 10mg online muscle relaxant withdrawal symptoms, Rangkadilok N baclofen 10mg discount spasms toddler, Sahasitiwat S purchase discount baclofen on line muscle relaxant lodine, Pholphana N purchase 25 mg baclofen free shipping muscle relaxant lactation, Ruchirawat S, Satayavivad J. This is understandable, since a drug is ing them back in order to repair the lesion. The clinical training environment should be one where students feel safe to ask questions. Note: Make no assumptions about the number of cores positive or examined based on the number of areas biopsied within the prostate (laterality, lobes, apex, base, or mid-prostate), because several cores may be taken from each area. Effect of rhynchophyllineonplatelet aggregation and lowered the systolic pressure by about 25%, diastolic pressure by experimental thrombosis. Integrating metastasectomy in the managemente of advance urological malignancies-when are we in 2005? The model and resulting distributions take into account the known differences in human physiology and metabolic capability with regard to dichloromethane dosimetry. Liver recurrence is very high but the best chemotherapy regimen in these cases is to be defined. Examine the corpus with serial point of deepest tumor invasion (in milli transverse sections as you would in any hysterec meters)? Caries-preventive effectiveness of a fuoride varnish: a randomized controlled trial in adolescents with fxed orthodontic appliances. These headaches may begin after a single trauma or following repetitive minor head impacts. Contraceptive efficacy and tolerability with a novel combined contraceptive vaginal ring, NuvaRing. Factors that could influence ablation volume, beside applied time and energy, include tumour type (hypervascular versus hypovascular tumours) and tissue elasticity or fibrosis, affected by underlying liver disease and chemotherapy. A third insemination was given at 36 hours to cows still in standing estrus after the second insemination. However the extent of the error appears quite limited in the rat and more predominant at high exposures versus low exposures in the mouse. However, echoic vessels, the liver texture itself tends to be of increasing success in the management of this con either normal echogenicity, or, in the later stages of dition, particularly in specialist centres, has failure, hyperechoic. These studies are in contrast to the Finlayson and Baumann (1956) study, which compared the effect of feeding rats urea mixed with a diet given ad libitum to a spaced feeding scheduled of 2 hours/ day. The interaction between Taraxacum mongolicum and ciproflox Further study is required to discover if, and under what circum acin is based on experimental evidence only. In the absence of metastatic disease, a surgical or medical consult documenting the reason for inoperability D. The use of cetuximab, bevacizumab, and trastuzumab in 5-year survival of less than 30% after gastrectomy (445,446). The simplest way to extract energy from Casimir cavities would be to release the closely spaced plates so that they could accelerate together. This is because the population in the southern counties is higher than the population in northern counties. The sample included 1,487 children from 0-5 years of age in government nurseries in Kingdom, measures changes in oral health since the last Southern Brazil. To generate structures that exhibit localized bending, budding, or Advances in cell and molecular biology as well as tissue engi branching, one cell or a small group of cells has to divide to expand neering have shed light on the nature of these local cues. Interleukin-22 numerous novel preclinical approaches offer further promise drives endogenous thymic regeneration in mice. Isodose Curves Penumbra: lateral spread, a function of source size as well as beam energy. The line represents the actual number of dentists; the bars indicate the annual growth rate. The challenges of cell-transplantation and genetic engineering for the treatment of diabetes and haemophilia. The percentages of children with and without caries that were correctly identified by the non-dental professionals. More worryingly, many adults were long interactions was assessed in a Medicare population, using a term users and most did not discuss this practice with their retrospective analysis of Cardiovascular Health Study inter doctor. The peri odontal-related publication con cerned the global burden of periodontitis (Kassebaum et al. Coloured Page 37 scanning electron micrograph (Yorgos Nikas, Science Photo Library). If the patient responded "yes" to the question on tobacco use a series of questions about the type of tobacco used, frequency of use, amount used and duration were asked. A reduced capillary and small vessels resilience may also contribute to peripheral blood steal, which may exacerbate various autonomic manifestations, such as nausea and bloating. Minorityy groups expeerience dispaarities similaar to those exxperienced bby those of llow 13 socioeconnomic statuss. In the meantime, we hope that the expert chapters in Stem Cells Handbook will provide useful and authoritative information to aid those who seek the answers to the unanswered questions. The positive effect on cognitive function claimed by many women taking estrogen remains to be confirmed. Inferring the fluoride hydrogeochemistry and effect of consuming No comparison between F fluoride-contaminated drinking water on human health in some endemic areas of Birbhum district, levels in drinking water West Bengal. They contain visceral organs and cavity abdominal serous membrane cavities: thoracic cavity Thoracic cavity is lined by cavity endothoracic fascia.

Complications of central venous catheters used for the treatment of acute hematogenous osteomyelitis order baclofen 25 mg without a prescription gastric spasms. Usage of adhesive bandages should be dissuaded buy cheap baclofen 25mg on-line spasms spasticity muscle, as blisters will appear quickly while the skin is pulled to discount baclofen 25mg on line spasms quadriplegic bring the edges of the wound together order baclofen 25 mg visa muscle relaxant vs anti-inflammatory. The prescribed assay procedure allows for the analysis of plasma from heparinized patients at heparin levels < 1U/mL plasma (un-fractionated and low molecular weight heparins) buy baclofen 10mg with amex spasms multiple sclerosis. Yearly costs of routine and additional imaging were 217 in the intensifed protocol and 191 in the control protocol (Table 2). The goal trials, (i) reporting of trials, (j) principles for defining of clinical communications is to enable autonomous, information in datasets as sensitive? such that there well-informed decision-making by patients. Most spontaneous abortions that occur during this period do not take place in a hospital or clinic where the tissue can be readily obtained. An important consideration is whether the remain effective until administration treated may be repaired using stem cells. Immunogenicity of iodine 131 chimeric tumor necrosis therapy monoclonal antibody in advanced lung cancer patients. William Cloud Peter McCutcheon Diana Toche Kim Conley Gene McElhinney Todd Tovarek Candie Crawley Michael McLaughlin David Trygstad Robert Crittendon Frank Mendoza Paula E. As the concentration of F in the drinking water increased to 4 ppm and 15 ppm, the prevalence of severe fluorosis was 16% and 64%, respectively Razdan et al. Less than 40 percent provide dental services in the other 53 counties in California (11 percent of dentists live out of state). First, sample a viable and rep should be 10 to 15 times that of the tissue being resentative area of the process to be studied. The guidance, to be used in conjunction with the summary of product characteristics of the licensed gene medicine (when available), also contains standard operating procedure templates. There is evidence that rat bone marrow adipocytes pro solution, incubated for 5 min in 0. If surgery is done, the pathologic stage (also called the surgical stage) is determined by examining tissue removed during an operation. A randomized controlled study of preemptive lamivudine in patients receiving transar? For myocardial perfusion imaging, we require the interpretive report and copies of the actual images in both grey-scale and color (in digital format or hard copy. Spine and Other 468 Guide for Aviation Medical Examiners Musculoskeletal, revise dispositions table for Arthritis. Pascazio, Phase Space Tweezers for Tailoring Cavity Fields by Quantum Zeno Dynamics,? Physical Review Letters 105, 213601 (2010). Statistically significant increases in benign mammary gland tumors were observed in one study of F344 rats exposed by inhalation to 2,000 or 4,000 ppm (Mennear et al. In this chapter we will look at these dilemmas and try to find out if there are any opportunities related to that specific stage of life or to a specific personal character and how these can be found. It is prudent to consider the least invasive option that will have similar sensitivity and specifcity to guide clinical decision making to minimize the potential for harm to the patient. The components of the report and format are describes including: demographics, relevant clinical information, body or report and impression. Melanoma Research, a potential chemopreventive strategy against hepatocellular vol. Thus the strength of evidence describing the all lost sealants were repaired in one of the 2-year studies, progression of early occlusal caries must be considered and repairs were performed routinely in the 5-year study. Metastatic disease can involve the dura either via direct extension from the bone or via hematogenous spread. Resection of a metastasis should be considered if less than 50% of the liver is involved and a minimum of 90% of the tumour burden Robotic-assisted surgery has been used to perform can be safely resected. Am J Two case reports describe muscular disorders in patients who Med Sci (2004) 327, 356?7. This spatial heterogeneity of cell fate fate decision, in addition to soluble growth factors and cytokines. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U. Even after apparently normal birth of livestock, embryos (surplus to fertility treatment or created specifically) premature postnatal deaths have been reported (Renard et al. Because inflammatory condition of the liver lying disease and of unknown etiol the prognosis depends on early treat in which the biochemical and histo ogy) and usually is associated with ment and individual responsiveness logic abnormalities persist for more inflammatory bowel disease. Teratomas typically contain a mixture of many differentiated or partly differentiated cell types?an indication that the embryonic stem cells are capable of differentiating into multiple cell types. This multigene assay is intended for use in lymph-node negative breast cancer patients. At 7 weeks of gestation, a sonolucent area is seen in the cephalic pole, presumably representing the fluid-filled rhombencephalic vesicle. Both the renal length and circumference increase with gestation, but the ratio of renal to abdominal circumference remains approximately 30% throughout pregnancy. For isolated hyperechogenic foci, the risk for trisomy 21 may be three-times the background risk. It was concluded that, in twin-to-twin transfusion syndrome, the donor twin shows evidence of a hyperdynamic cardiac state. Dig Dis biopsy in England and Wales: an audit by the British Society of Gastro Sci 1998;43: 46-50.

When drug therapy is ineffective on convulsive seizure discount 10mg baclofen mastercard spasms hand, resection of the brain hemangioma is conducted order 25 mg baclofen overnight delivery spasms by rib cage. Reported risks of the patient order baclofen with mastercard muscle relaxant 563 pliva, whether disease is synchronous or metachronous purchase 10mg baclofen amex spasms perineum, and associated with chemotherapy include the potential for development of the response rates and safety/toxicity issues associated with the Version 3 10 mg baclofen with visa spasmus nutans. Hypersalivation (of amyotrophic lateral sclerosis) It is well known that radiation will decrease saliva production as a consequence of treating head and neck cancer. To date, there is very little evidence that these concerns represent real Future prospects, problems, concerns and problems, but we have to be careful to continue open questions research with long-term studies designed to eval uate the chronic effects of stem cell therapy. Radiology of the Postoperative Digestive Tract Bruce Javors, Ellen Wolf, Springer, 2003 29 3. Whelton H, Crowley E, Nunn J, Murphy A, Kelleher V, Guiney H, Cronin M, Flannery E. Introduction Joint hypermobility is defined as an increased range of movement in one or more joints. Diagnostic staging determines the extent of local disease and presence or absence of regional or distant metastasis. Patients with rheumatoid arthritis frequently choose not to drive during periods of exacerbation of their arthritis or following joint replacement 23 and there is good reason to support this approach. The endothelial lining is therefore large in area and has a phagocytic activity as part of the reticuloendothelial system. ColonSentry the ColonSentry test (GeneNews, Toronto, Canada) measures the expression of seven genes, which serve as biomarkers to detect colorectal cancer. In patients with colorectal liver metastases, can we still rely on number to define treatment and outcome? What are the main challenges, considerations, and enablers to the cessation of community water grey literature fluoridation programs in Canada? For chromogen development, the SlideMaster unit has a contrast Slide Holder Stainless Steel Rack (for 30 Slides) bar that changes the background from black to white. The studies were conducted in East Germany, Cuba, and Czech Republic, and were assessed as having a high risk of bias. Tese localized characterized by difuse enlargement of the thyroid degenerative and reparative changes produce some up to several times normal size. Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia. If you are not able to tolerate the regimens shown in Guide 18, beginning supportive care is an option. Lerner and Ihor Sawczuk; Cervical Cancer: Katja Gaarenstroom (Chair), Johannes Bonfrer; Gastric Cancer: Johannes Bonfrer (Chair), Johanna Louhimo. On the other hand, the high-dose arm was associated with a non-significant reduction in local-regional persistence or failure (50% vs. As mentioned previously, in the automotive industry, urea is utilized as a reductant in selective catalytic reduction. An 80-Gene Molecular Subtyping Profile (BluePrint) was developed using 200 breast cancer patient specimens and confirmed on 4 independent validation cohorts (n = 784). The sagittal sequence with T2 information showed discal and osteophytic changes prognosis; however, recurrent forms make differentiation from of the vertebral bodies associated with bulging of the inferior annulus and thickening and hypersensitivity of the cervical spinal cord from the craniocervical junction down to C7. If there are too few cells, the cord blood unit may be used for research to improve the transplantation process for future patients, or it may be discarded. This single dose of propranolol did not have any effect on blood pressure or heart rate in these particular subjects,1 so it was 1. Any large tissue fragments, that is, tents of the container, and give an estimate of the fragments greater than 3 to 4 cm, should be sec amount of the specimen by volume (in cubic tioned and entirely submitted if they are? The best resolution of the sonogram occurs when the B-mode image and color image are frozen, allowing all the time to be employed for spectral Doppler. Intervention Hip Replacement Surgery Minimum eligibility Referral is based on local referral pathways. Proliferation of totipotent hematopoietic stem cells in vitro with reten Brunner, G. Treatment of orbital rhabdomyosarcoma: survival and late effects of treatment?results of an international workshop. These are associated with lower pain scores but neither procedure has long term outcomes data available yet. The acids in your mouth attack your tooth enamel the hard outer layer of each tooth and can cause decay. Consistent with this, escargot (esg), even though the exact timing and the number of premeiotic sper encoding a transcription factor with zinc-finger motifs, is matogonial divisions varies from species to species. Research with existing stem cell lines derived from human embryos can be federally funded if the stem cells are included 26 on an official list of authorized lines. Systematic review and meta-analysis of randomized controlled trials of cognitive behaviour therapy and behaviour therapy for chronic pain in adults, excluding headache. Depending on clinical symptoms vic lymphadenectomy may be an option in patients with small and physical fndings, additional cytological or histological tumors (< 2 cm in diameter; 374). Publication status and date: Edited (no change to conclusions), published in Issue 3, 2018. The pathogenicity of the dental plaque biofilm is 1 Journal of Dental Hygiene, Vol. One occupational study showed that exposure to urea increased levels of potential carcinogenic biomarkers but these increases were within the normal physiologic range Chronic studies in rats and mice have shown no treatment related increase in tumors following either oral or s. Early opioid prescription and subsequent disability among workers with back injuries: the Disability Risk Identification Study Cohort. In this situation, the modifier 62 may be appended to code(s) 22210-22214, 22220-22224 and, as appropriate, to associated additional segment add-on code(s) 22216, 22226 as long as both surgeons continue to work together as primary surgeons.

Ultrasound appearances There are three classic acoustic properties associ ated with stones in the gallbladder; they are highly reflective purchase baclofen discount muscle relaxant 750 mg, mobile and cast a distal acoustic shadow purchase generic baclofen pills zoloft spasms. Bromelain appeared to discount baclofen 10 mg with mastercard muscle relaxant kidney stones the reason for this interaction is unclear generic 25mg baclofen amex muscle relaxant pills over the counter, but it is possible that increase the serum levels of tetracycline by up to purchase 10mg baclofen visa muscle relaxant liquid about fourfold. Univariate analyses indicated that local recurrence rates were adenomas are grade 3 or 4, angiolymphatic invasion, or a positive low for patients who had tumors with an inferior margin of 10. It is important to recognize, however, that grades Despite the vast number of possible combinations were not strictly comparable between diferent of these variables, there are in fact relatively few systems of classifcation. Note that the coumarin anticoagulants used page 258, it is not possible to generalise about their group clinically (acenocoumarol, phenprocoumon, warfarin) are actions, and this also applies to their toxic and drug all synthetic 4-hydroxycoumarins. Primary Care physician willingness to provide follow-up care for adult cancer survivors. Combined treatment = We invited participants to attend eight sessions of manipulation over six weeks, eight sessions of exercise in the next six weeks, and a refresher class at 12 weeks. Hepatomegaly is also a Haematoma Haemolytic process feature, though not invariably. Kitchens can also be adapted using pull-out worktops, ceramic cooking plate for sliding rather than lifting pans onto, or a hob tap? from which pans can be filled with water at the cooking plate. When you do go home, you might need to stay near the transplant center for some time, depending on your condition. Recognized causes are tumour in the cerebellopon Description: Classical trigeminal neuralgia without per tine angle, arteriovenous malformation and multiple sistent background facial pain. For melanomas located optic nerve (P-O) section?which includes the posterior to the equator, the anterior segment pupil, optic nerve head, and macula in the same (cornea, iris, lens, and pars plicata) is removed section. Most therapeutic mAbs are complete immunoglobulin gamma (IgG) molecules which consist doi: 10. Chaudhary and Ronninson but with a marker, usually a hemoglobin with an electrophoretic (1991) have shown that P-glycoprotein, a cell membrane protein mobility difference. Retinal cell-cell differentiation is initiated in the central neurons, each in turn comprising several subtypes. Co authors will be the members of the writing committee and investigators who have recruited patients to the study. For example, add together the lengths of intermediate repairs to the trunk and extremities. The distribution in the Mayo 26 clinic series showed a higher proportion of complications in the thoraco-abdominal region. It is likely that local geographical and service factors influence the most effective method of providing multidisciplinary care for those with more severe problems. In developing tissues, such as branch more as triggers of latent programs since the same molecules are ing capillary networks or budding epithelial glands (Fig. By speaking with one voice,? the practice owner, it is important to use lay terminology or medical vocabulary minimizes the potential for confusion and disillusionment by the accompanied by a clear explanation. Trikatu was found to significantly reduce the ments in patients taking nevirapine. Semi-skimmed milk is not a suitable drink for children Semi-skimmed and skimmed milk lack essential under 2. The determination of ulceration is based on several pathologic criteria and must be microscopically confirmed. Exercise reduces sick leave in patients with non-acute non-specific low back pain: a meta-analysis. Many of these difculties are due to the physical efects of chemotherapy and radiation treatments. Socioeconomic status also influences the likelihood of liver resection, where the socioeconomically favoured population are resected to a greater extent (100). Rarely, one may fnd 260 Endodontics 11 Access Cavity and Endodontic Anatomy 261 a single, elliptical canal in a single root; more often, cording to other authors89 one may fnd three roots one fnds two canals with separate apical foramina in containing three canals with independent apices. Fab arms are responsible for antigen Antibody molecules can be made more efcient by engineer binding and have been extensively engineered for developing ing additional specifcities so that multiple antigens or epitopes highly specifc and synthetic antibodies against numerous targets present on a cell can be targeted (17, 18). Systemic antifungals indicated for moderate to severe nail infection can result in a variety of drug-drug interactions and confer increased risk for heart and liver failure. With regard to children, it is also this stage, the treatment consists in restoring the affected important to consider their caregivers? life style. Using color Doppler in an apical or basal approach, the diastolic perfusion across the atrioventricular valves can be assessed (Figure 14). During serial passage in cul protein is believed to have functions in host interactions. It is important to complete the double contrast esophagram as quickly as possible. In contrast, brain levels of dichloromethane in rats exposed for 1 week were higher than brain levels in rats exposed for 2 weeks. We first discuss a simple analytical solution for 1D case, which is depicted in Fig. Odynophagia and globus sensation are common symptoms and the differential diagnosis can be extensive, including infammatory, infectious, neoplastic, autoimmune and traumatic causes. The contemporary review tries to disclose the role of streptococcus Received: June 09, 2019 | Published: July 17, 2019 mutans in dental clinical conditions.

To protect the for example order baclofen online spasms on left side of abdomen, factors that could unblind research ability to discount baclofen 25mg mastercard spasms right side abdomen draw valid conclusions about clinical benefit cheap 10mg baclofen with mastercard muscle relaxants knee pain, subjects or investigators discount baclofen 10mg with amex muscle relaxer z. Prognosis Sacrococcygeal teratoma is associated with a high perinatal mortality (about 50%) generic 25 mg baclofen amex spasms meaning, mainly due to the preterm delivery (the consequence of polyhydramnios) of a hydropic infant requiring major neonatal surgery. In recent years, the emphasis on the reasons why people fail to achieve a healthy adjustment has shifted to the identification of factors that help patients make that adjustment. Pancreatology 2012;12: 198?202 endoscopic retrograde pancreatography and endoscopic ultrasonography, 124. Referral to a specialized centre for diagnosis and long-term management is recommended. The testing of a person to rule out or to confirm a suspected diagnosis because the patient has a sign and/or symptom is a diagnostic test, not a screening. Nausea and vomiting 2 Because chemotherapy drugs can cause severe nausea and vomiting, doctors often give anti-nausea medicines at the same time as chemo to try to prevent it. Recognising the signs of infection can mechanical cleansing and debridement using, be challenging and there may only be subtle if wound dimensions allow, an agent such as a changes in the wound such as delayed healing, monofilament debridement pad, wound irrigation discolouration of the wound bed or friable, with sodium chloride 0. We have also 10 shown that such lasers can be operated at high speed, as a result of a strong localization of light, implying that coupled nanocavity arrays can be an effective way to achieve high power and high-speed single mode laser sources. X-rays: manufactured by electron beam striking tungsten target, no mass or charge 3. The three vessel view will enable the assessment of the aortic arch and the ductus arteriosus. For example, Dural Tear if the surgeon injures an anterior thoracic or abdominal organ while performing posterior spine surgery without appropriate Incidental durotomy is an underestmated and relatvely adverse precautons, that would be a breach of standard of care. P-glycoprotein by schizandrin, and possibly other related com pounds, may have resulted in increased absorption of tacrolimus. They will be given through your central venous catheter, much like a blood transfusion. Aims: We have shown that in vivo biotinylated single-chain (scFv) used as capture reagent decrease the incident of interference from heterophilic antibodies (Warren et al. The involvement of the two horns au completed, the instrument can be introdu gles, seen in a mesiodistal projection. Patients with a hypermobility syndrome can easily be missed in orthopaedic practice. Practice parameters: magnetic resonance imaging in the evaluation of low back syndrome. To optimally transfer power from a source, in this case the noisyat ambient (equilibrium) temperature. Anamnesis in combination with traditional drugs for osteoporosis was directed to the discomfort in the oral cavity: dryness, treatment, such as 17-estradiol, increases bone formation itchiness/parestesia, bitterness and cough; the patients in the jaw, especially in the alveolar bone. Small series show excellent outcomes, but careful informed consent necessary for non-standard therapy (Farhi) D. The presented examples of outcome measures are derived from literature and personal experience of the authors. This new fluorapatite (or fluor-hydroxy-apatite) is actually considered at risk for dental caries. Risk that adnexal mass is malignant 7-13% (premenopause), and 30-45% (postmenopause) (Koonings) D. Also, the outcome assessment is based on mortality (underlying cause from death certificates) rather than incidence data, and, because the Kodak studies were limited to men, there is no information on risk of breast cancer or other female reproductive cancers. For flow cytometry, red cells were lysed, and then nucleated cells were concentrated by ficoll gradient centrifugation and put into aliquots. In terms of activation analysis, K, Mg, Zn, Cu, and Fe by the atomic molar concentrations the concentrations are frequently of the absorption method, and F with the fluoride specific electrode. Exposure to urea via food caused an increase in protein synthesis and decreased the density of secretory granules in pituitary intermediate cells (Okada and Kobayashi, 1989). For these reasons, the literature generally does not recommend p53 analysis as a routine approach to assisting in the management of patients with colorectal cancer. The only accurate method for determining the severity of the disease is blood sampling by cordocentesis and measurement of the fetal hemoglobin concentration. Clinical testing should never allow promise Ethical principles and guidelines help secure the basis for future patients to override the welfare of for this collective effort. Flow cytometry allows simultaneous measurement of cell size, granularity as well as four (or more) different fluorochromes. Infants with hemodynamically significant shunt the registry from institutions worldwide. The risk/benefit ratio of colorectal cancer screening or surveillance for any patient should be individualized based on the results of previous screening examinations, family history, predicted risk of the intervention, life expectancy and patient preference. All forms of inheritance have been described, including autosomal dominant, autosomal recessive, X-linked dominant and X-linked recessive. Importance and management Although evidence appears to be limited to this one study, it is Flavonoids + Quinine or Quinidine supported by in vitro data that suggest the absence of an interaction. The highest score of all the teeth in the sextant was entered in the appropriate box begin ning with the upper right sextant and proceeding to the lower left sextant. This publication is the long-term follow-up to the study by Ritvanen 2007, although short-term outcomes are also reported in this publication.

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References:

• http://retinatoday.com/pdfs/0719rt_Cover_Nagiel(updated).pdf
• https://www.analysisgroup.com/uploadedfiles/content/insights/publishing/the_biopharmaceutical_pipeline_report_2017.pdf
• https://www.ihe.ca/download/standard_quality_assessment_criteria_for_evaluating_primary_research_papers_from_a_variety_of_fields.pdf